Who?
Sulfonylureas and meglitinides are recommended for persons with type 2 diabetes who have poorly controlled blood glucose levels. On average, most patients find that their Hb A1c levels drop by up to 1.5% on these medications.
What?
Oral tablets – sulfonylureas stimulate the pancreas to release insulin over a period of several hours. Common brands include:

Meglitinides stimulate a shorter term burst of insulin to cover mealtimes. Common brands include:

Where?
Sulfonylureas and meglitinides work by stimulating the pancreas to release insulin.
When?
Sulfonylureas are usually taken once or twice a day, in the morning and/or evening, depending on the brand:
  • Chlorpropramide is taken once a day (typical daily dose: 100 mg to 500 mg)
  • Glipizide is taken once or twice a day (typical daily dose: 5 mg to 40 mg)
  • Glyburide is taken once or twice a day (typical daily dose: 1.25 mg to 20 mg)
  • Glimepiride is taken once a day (typical dose: 1 mg to 4 mg; maximum 8 mg daily)

Meglitinides are usually taken 15-30 minutes before each meal:

  • Repaglinide is taken at doses ranging usally from 0.5 mg to 4 mg with each meal
  • Nateglinide is taken at doses ranging usually from 60 mg to 120 mg
Why?

 

 

 

 

Print Friendly, PDF & Email
Skip to content